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Inhibition of the enzyme raises blood levels of both and leads to feelings of happiness. Gleevec (imatinib), a drug that dramatically increases the survival rate in chronic myelocytic leukemia (CLM), was developed based on the finding that CML patients produce an abnormal version of the enzyme tyrosine kinase, which in turn leads to an overproduction of white blood cells. In some cases, the effectiveness of a drug for an ailment was discovered when it was being used for a different condition. You could look at it half full and feel glad that the cheats are finally being caught. Its ghoulish-looking teeth - which some say look like an old guy's dentures - are found on its bottom side. You could look at the glass half empty and bemoan the fact that doping seems to be so widespread in sport. "Serious sport has nothing to do with fair play," George Orwell once wrote. Indeed, in some sports such as cycling, not doping may well be an entry barrier at the highest levels of the sport. Another huge doping scandal of recent times was Operaci Puerto, which revolved around a doctor named Eufemiano Fuentes, who ran systematic doping services for some of the biggest names in cycling, as well as for a few tennis and football players.
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